The Acolapissa were Choctaw speaking hunter/farmers of the lower Mississippi River in Louisiana. They occupied the Natchitoches for some time, having a battle upon their separation. After decimation by a smallpox epidemic, and having suffered a slaving raid by the British and Chickasaw, this tribe allied with the French.
They ultimately confederated with the Houma and followed their fortunes. Eventually, the remaining Acolapissa were absorbed into the Houma tribe in Louisiana.
| Year | History |
| 1697 | Smallpox epidemic |
| 1698 | Encountered d’Bienville, Acolapissa had just been in battle with British and Chickasaw (slaving raid) |
| 1701 | Acolapissa sold by Virginians as slaves for the Carribbean Islands |
| 1702 | Had suffered population losses due to previous epidemic, removed from Pearl River to Lake Ponchartrain, joined by Natchitoches |
| 1714 | Battle with Natchitoches causing separation |
| 1718 | Moved across Mississippi River to near New Orleans |
| 1739 | Joined Houma and followed their fortunes |
